Synthesizing aspirin and oil of wintergreen purpose in this experiment, you will synthesize acetylsalicylic acid, commonly known as aspirin, and methyl salicylate, oil of wintergreen, from salicylic acid. In this episode we look at water baths, heaters and melting point apparatus, thinlayer chromatography and the purification of organic solids. The active pharmaceutical ingredient api and main component of aspirin is 2ethanoyloxybenzenecarboxylic acid ch 3 cooc 6 h 4 cooh. The uses,doses and side effects are also in these p. Solution manual engineering mechanics statics 12th edition by rchibbeler. Practical 4 determination of an enthalpy of neutralisation. It includes how organic compounds are purified and how purity is tested. These principles include learning the basic techniques of the process of organic synthesis, determining the percent yield of a product, and lastly being able to properly dispose organic waste products. Aspirin contains polar functional groups which can form hydrogen bonds with polar water molecules.
The hammett equation correlating the dissociation constants k for the substituted acid and k0 for the unsubstituted acid of members of a closely related series of acids is given by logkk0 p. This activity, from the royal society of chemistry, extends the range of study of acids and bases to the context of medicines. This interactive resource introduces students to the aspirin synthesis and coaches them through the steps needed to complete a. History organic chemistry history the chemistry department at the norwegian institute of technology was established in 1910, and when teaching started in the autumn of that year there were four institutes. This reaction is the reverse of the synthesis reaction. This resource allows students to run their own synthesis. Reactions of aspirin, i distinction from salicylic acid. Pain relief and more chemsumer b ut before you settle into channel surfing, think about that bottle of aspirin or ibuprofen. This book, published by the royal society of chemistry, consists of eight freestanding activities based on the organic synthesis of aspirin.
Add 6 ml of acetic anhydride and 58 drops of 85% phosphoric acid to the flask. Place a 250 cm3 beaker, halffilled with water, on top of a tripod and gauze. Everyday low prices and free delivery on eligible orders. Stroke is a rare disease in childhood with an estimated incidence of 16100. What does the american indian shaman collect in the forest. What makes our format different is the use of a wide range of spec.
Practical 1 aspirin titration in this experiment you will determine the percentage purity of aspirin in two different strengths of over the counter aspirin tablets by performing a titration with sodium hydroxide. An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. Chemistry, biological and medicinal chemistry with a year in york. Unit 4 practical course practical 1 simple organic tests 1 practical 2 simple organic tests 2 practical 3 the preparation and identification of a 2,4dnph derivative practical 4 the preparation of aspirin practical 5 the preparation of ethyl ethanoate practical 6 using thin layer chromatography to separate the pigments in chlorophyll. Aspirin is only slightly soluble in water and acidic solutions such as is present in the stomach. They plot a graph of ph against volume of sodium hydroxide solution added and use the ph at the halfway point to determine the pka of aspirin. Aspirin is more soluble in basic alkaline solutions, so it readily dissolves in. What substance does the doctor of the grand duchess prescribe as a remedy for her arthritis. University chemistry spectrophotometric analysis of.
Aspirin, also known as acetylsalicylic acid, has a chemical formula of c9h8o4. Reviewing over a century of aspirin research and use, aspirin and related drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin. Terms in this set 30 how was fever and pain treated before aspirin was created and by who. Core practical aspirin nazarbayev university chemistry. Practical work brings science to life, helping students make sense of the universe around them.
It is also an antiinflammatory agent, providing some relief from the swelling associated with arthritis and minor injur ies. It is the twostep synthesis of aspirin starting from oil of wintergreen. If you will be calculating actual and theoretical yield, be sure to record how much salicylic acid you actually measured. If the liquid is pure it will have the boiling point referred to in data books. Practical, synthesis of aspirin, questions and answers. Aspirin or acetylsalicylic acid is a drug in the family of salicylates, often used as an analgesic against minor pains and aches, antipyretic against fever, and antiinflammatory. Synthesise aspirin from 2hydroxybenzoic acid objectives. Aspirin is used medically to reduce fever and pain. If the chromatographic behavior of the substance under investigation is unknown, the. It has an increasingly recognised impact on child mortality along with its outcomes and effects on quality of life of patients and their families. Information is provided on the historical development and properties of paracetamol. The activities can be used individually or as a coherent package in a wide range of teaching and learning situations in both academic and vocational courses. You will be able to see how two very different organic compounds can be made from the same common starting material. Aspirin, one of the first drugs to come into common usage, is still mostly the widely used in the world approximately 35,000 metric tonnes are produced and consumed annually, enough to make over 100 billion standard aspirin tablets every year.
This figure mainly reflects purchase of 16,000 tons of aspirin tablets or 80 million tablets a year. Structure, properties, spectra, suppliers and links for. This can build up inside containers and pressurise them. Although labs involving aspirin are common, they are useful because these labs help general chemistry students relate chemistry to realworld problems. Students titrate a solution of the aspirin against a strong alkali, such as sodium hydroxide solution. Analytical, transition metals, electrochemistry and organic nirtrogen chemistry. Introduction aspirin is an analgesic and antipyretic salicylate drug. Determine the identity of an unknown chemical substance kit contents qty item description 3 reaction plate 1 wax pencil 1 powdered aspirin, 5 gm 1 unknown presumed to be sugar, 5 gm 1 unknown presumed to be salt, 5 gm 1 unknown presumed to be cornstarch, 5 gm 1 distilled water, 10 ml 1 sodium hydroxide 1m, 10 ml.
Determination of salicylic acid in aspirin analytical. Preparation of aspirin experiment 5 introduction in this experiment you will prepare a sample of aspirin, recrystallize the raw product, and determine the percentage yield of the aspirin based on the limiting reactant. It relieves your pain, reduces the inflammation swelling, and generally makes you feel better. The mechanism for this synthesis provides examples of three major classes of chemical reactions. Allow the conical flask to cool slowly and white needles of aspirin. As the reaction proceeds, the solid salicylic acid disappears and the acetylsalicylic acid product. Users may need to adapt the risk assessment information to local circumstances. Practical work in reformed alevel biology, chemistry and physics. In industry, ethanoic anhydride is used rather than ethanoyl chloride for practical purposes. The synthesis of aspirin procedure steps 3 5 were repeated twice more for two more titrations.
Practical 3 determination of an equilibrium constant. Aspirin possesses a number of properties that make it the most often recommended drug. Quantitative analysis of aspirin further analysis conclusion the overall objectives of. The interactive tool enables students to undertake an aspirin synthesis, perform recrystallisations, thin layer chromatography and modify experimental conditions to determine the effect on yield. Aspirin could be synthesized by the esterification of the phenolic hydroxyl group of salicylic acid. Ethanoyl chloride is very reactive with water and any moisture produces hydrogen chloride gas. Clamp a 50 cm3 roundbottomed flask so that it is partially submerged in the beaker of water, and fit a. From gunpowder to graphene, 250 milestones in the history of chemistry sterling milestones by derek lowe isbn. This guide includes details about the pags for alevel chemistry. This book, published by the royal society of chemistry rsc, consists of seven freestanding activities that can be used individually or as a coherent package in a wide range of teaching and learning situations in both academic and vocational courses. The aspirin screen experiment is a freely available digital resource. Nonaspirin definition of nonaspirin by merriamwebster. Lab a inorganic chemistry, lab b organic chemistry, lab c technicalinorganic chemistry, and lab d technicalorganic chemistry.
Clarify the importance of keeping a lab book or other records of practical work. Students undertake the synthesis and analysis of aspirin. Aspirin book resource rsc education royal society of chemistry. In lab today, we measured the actual yield and melting point of aspirin that we had made in lab last week. Ap chemistry ap physics thermodynamics gas laws chemical reactions general chemistry college chemistry chemistry measurement word problem chemistry lab chemistry conversion. You can also buy a copy of this book via the royal society of chemistry online.
Organic chemistry synthesis of aspirin flashcards quizlet. Practical science allows scientific theory to transform into deep knowledge and understanding scientific thinking. In doing so, several procedures with be completed, using various items including salicylic. Aspirin is a very effective painkiller and fever reducer, but it causes sideeffectsin some people. Practical 6 using thin layer chromatography to separate the pigments in chlorophyll. Aspirin acetylsalicylic acid is a painrelieving compound. Find out about the science and chemistry of aspirin acetylsalicylic acid, bayer, see colourful images of aspirin and explore interactive 3d molecules of aspirin. Nonaspirin definition is not being or containing aspirin. Though aspirin is much less irritating than plain salicylic acid, it causes stomach upset in a very small percentage of people.
Core practical 16teacher sheet synthesise aspirin from 2hydroxybenzoic acid practical activities have been safety checked but not trialled by cleapss. In the laboratory confessions podcast researchers talk about their laboratory experiences in the context of a level practical assessments. Aspirin one of the most widely used drugs worldwide. Thats why weve put practical work at the heart of our biology, chemistry and physics alevels. Aspirin is also an antipyretic compound, which means it reduces fever. Chemistry aspirin lab question wyzant ask an expert. H 2 so 4 use a dropper, h 2 so 4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves heat the flask gently on the steam bath for at least 10 minutes. To what group of chemicals do willow tree bark, oil of wintergreen, and aspirin belong. In the presence of moisture, aspirin may decompose hydrolysis into salicylic acid and acetic acid.
Abstract the synthesis of aspirin lab has many goals and objectives it wishes to accomplish. At california state university, fullerton, the firstsemester general chemistry. I was supposed used 1 g of aspirin and 20 cm3 of ethanol for a titration with naoh. Vce chemistry unit 3 2015 internal assessment guidelines. Aspirin synthesis lab report by alissa lockwood on prezi. Synthesis of aspirin experiment chemistry libretexts. A2 chem aspirin practical help please the student room. Aspirin is one of the milder and least expensive pain relievers available. Synthesising aspirin throughout june and july, the university of readings department of chemistry have played host to pupils from 9 local schools, who have visited the department to take part in the reading chemlabs aspirin synthesis practical. The preparation of aspirin core practical 10a stage 1. It is a derivative of salicylic acid which is also an. Studies on the metalcomplex of acetyl salicylic acid aspirin.
1054 1203 912 513 83 972 986 541 305 1100 1157 752 1589 782 1403 1438 1462 352 1299 980 737 1553 612 40 571 241 19 79 579 883